Vincristine is an anti cancer drug that works by proventing microtubules from disassembling.?

8>How does this property make it a good drug?
Reply:It's actually the opposite. Vincristine prevents ASSEMBLY of microtubules, thereby inhibiting the mitotic process of cells.





The basis behind a majority of chemotherapy drugs is to limit the growth of all rapidly dividing cells which includes cancer cells. Microtubule formation is essential for mitotic replication, and so the prevention of microtubule formation equates the inhibition of cancer cell proliferation...But it also leads to a lot of negative side-effects.
Reply:That means, keeps the live tissue intact %26amp; doesn't alow the cancer 2 penetrate the cells.
Reply:See Jason's answer. It is very good and accurate.


Vincristine, and its other related cousins, work by preventing microtubule assembly. Paclitaxel and docetaxel prevent microtubule disassembly. Either way, inhibition of the microtubule apparatus serves to inhibit chromosomal separation and movement of molecules within the cytoplasm.





It does have toxicities, however. Principally these are neurologically-related: constipation, hand/foot sensory toxicity (tingling, numbness, etc.), and foot drop.

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